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      Solid tumor-derived target cell susceptibility to macrophages and natural killer/natural cytotoxic cells in the rat.


      Animals, Cell Transformation, Neoplastic, Cells, Cultured, Cytotoxicity, Immunologic, Immunity, Innate, Killer Cells, Natural, immunology, Lymphocyte Activation, Lymphoma, Macrophage Activation, Macrophages, Neoplasm Transplantation, Neoplasms, Experimental, Propionibacterium acnes, Rats, Rats, Inbred Lew, Rats, Inbred Strains

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          Cytotoxic capacity of rat macrophages (M phi) and natural killer (NK)/natural cytotoxic cells (NC) against adherent growing, solid tumor-derived target cells was evaluated, modulating the activation status of effector cells and growth conditions of target cells. Testing a panel of target cells, cytotoxicity of NK/NC and M phi was strikingly correlated so that besides of target-cell binding structures basic lysability seems to be of influence with respect to cytotoxicity rates. Varying the in vivo growth conditions of target cells altered their lysability by M phi and NK/NC cells in the sense that ascitic versus subcutaneously (sc) grown tumors were more resistant to lysis. On the other hand, in vitro culturing did not influence susceptibility for M phi, but with some tumor lines increased lysis by NK/NC cells was observed. In the rat, the activation status of M phi and NC was not age-dependent, and NK cell activity only declined slowly with age. But cytotoxic potential of M phi obviously presents a strain characteristic, different from NK/NC cell activity, only the latter two correlating in different rat strains. Experiments to augment natural cytotoxic capacity revealed that application of Corynebacterium parvum (CP) activated M phi and NK/NC cells, while sc tumor implantation only resulted in increased NK/NC cell cytotoxicity, leaving M phi unaltered.

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