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      Cobalt-Catalyzed CH Cyanation of Arenes and Heteroarenes

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      Angewandte Chemie International Edition
      Wiley-Blackwell

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          Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.

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            C-H bond activation enables the rapid construction and late-stage diversification of functional molecules.

            The beginning of the twenty-first century has witnessed significant advances in the field of C-H bond activation, and this transformation is now an established piece in the synthetic chemists' toolbox. This methodology has the potential to be used in many different areas of chemistry, for example it provides a perfect opportunity for the late-stage diversification of various kinds of organic scaffolds, ranging from relatively small molecules like drug candidates, to complex polydisperse organic compounds such as polymers. In this way, C-H activation approaches enable relatively straightforward access to a plethora of analogues or can help to streamline the lead-optimization phase. Furthermore, synthetic pathways for the construction of complex organic materials can now be designed that are more atom- and step-economical than previous methods and, in some cases, can be based on synthetic disconnections that are just not possible without C-H activation. This Perspective highlights the potential of metal-catalysed C-H bond activation reactions, which now extend beyond the field of traditional synthetic organic chemistry.
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              Oxidative coupling of aromatic substrates with alkynes and alkenes under rhodium catalysis.

              Aromatic substrates with oxygen- and nitrogen-containing substituents undergo oxidative coupling with alkynes and alkenes under rhodium catalysis through regioselective C-H bond cleavage. Coordination of the substituents to the rhodium center is the key to activate the C-H bonds effectively. Various fused-ring systems can be constructed through these reactions.
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                Author and article information

                Journal
                Angewandte Chemie International Edition
                Angew. Chem. Int. Ed.
                Wiley-Blackwell
                14337851
                March 16 2015
                March 16 2015
                : 54
                : 12
                : 3635-3638
                Article
                10.1002/anie.201409247
                6605f42b-6ff1-4563-865c-f93fc0098809
                © 2015

                http://doi.wiley.com/10.1002/tdm_license_1.1

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