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G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.
Atsushi Nakamura
1 ,
Masahide Fujita ,
Hiroko Ono ,
Yoshie Hongo ,
Tomoe Kanbara ,
Koichi Ogawa ,
Yasuhide Morioka ,
Atsushi Nishiyori ,
Masahiro Shibasaki ,
Tomohisa Mori ,
Tsutomu Suzuki ,
Gaku Sakaguchi ,
Akira Kato ,
Minoru Hasegawa
Jan 2014
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Abstract
Oxycodone and morphine are μ-opioid receptor agonists prescribed to control moderate-to-severe pain. Previous studies suggested that these opioids exhibit different analgesic profiles. We hypothesized that distinct mechanisms mediate the differential effects of these two opioids and investigated the role of G protein-gated inwardly rectifying potassium (K(IR)3 also known as GIRK) channels in their antinociceptive effects.