For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
14
views
90
references
 Top references
cited by
19
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      399
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Gene editing in birds takes flight

      research-article
      Author(s): , ,
      Publication date (Electronic):
      Journal: Mammalian Genome
      Publisher: Springer US

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The application of gene editing (GE) technology to create precise changes to the genome of bird species will provide new and exciting opportunities for the biomedical, agricultural and biotechnology industries, as well as providing new approaches for producing research models. Recent advances in modifying both the somatic and germ cell lineages in chicken indicate that this species, and conceivably soon other avian species, has joined a growing number of model organisms in the gene editing revolution.

          Related collections

          Most cited references90

          • Record: found
          • Abstract: found
          • Article: not found

          A TALE nuclease architecture for efficient genome editing.

          Jeffrey Miller, Siyuan Tan, Guijuan Qiao … (2011)
          Nucleases that cleave unique genomic sequences in living cells can be used for targeted gene editing and mutagenesis. Here we develop a strategy for generating such reagents based on transcription activator-like effector (TALE) proteins from Xanthomonas. We identify TALE truncation variants that efficiently cleave DNA when linked to the catalytic domain of FokI and use these nucleases to generate discrete edits or small deletions within endogenous human NTF3 and CCR5 genes at efficiencies of up to 25%. We further show that designed TALEs can regulate endogenous mammalian genes. These studies demonstrate the effective application of designed TALE transcription factors and nucleases for the targeted regulation and modification of endogenous genes.
          Article 0 comments Cited 704 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Targeted genome editing across species using ZFNs and TALENs.

            Andrew Wood, Te‐Wen Lo, Bryan Zeitler … (2011)
            Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species.
            Article 0 comments Cited 233 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells.

              M. Takata, M S Sasaki, E Sonoda … (1998)
              Eukaryotic cells repair DNA double-strand breaks (DSBs) by at least two pathways, homologous recombination (HR) and non-homologous end-joining (NHEJ). Rad54 participates in the first recombinational repair pathway while Ku proteins are involved in NHEJ. To investigate the distinctive as well as redundant roles of these two repair pathways, we analyzed the mutants RAD54(-/-), KU70(-/-) and RAD54(-/-)/KU70(-/-), generated from the chicken B-cell line DT40. We found that the NHEJ pathway plays a dominant role in repairing gamma-radiation-induced DSBs during G1-early S phase while recombinational repair is preferentially used in late S-G2 phase. RAD54(-/-)/KU70(-/-) cells were profoundly more sensitive to gamma-rays than either single mutant, indicating that the two repair pathways are complementary. Spontaneous chromosomal aberrations and cell death were observed in both RAD54(-/-) and RAD54(-/-)/KU70(-/-) cells, with RAD54(-/-)/KU70(-/-) cells exhibiting significantly higher levels of chromosomal aberrations than RAD54(-/-) cells. These observations provide the first genetic evidence that both repair pathways play a role in maintaining chromosomal DNA during the cell cycle.
              Article 0 comments Cited 222 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Mark E. Woodcock: mark.woodcock@roslin.ed.ac.uk
                Journal
                Journal ID (nlm-ta): Mamm Genome
                Journal ID (iso-abbrev): Mamm. Genome
                Title: Mammalian Genome
                Publisher: Springer US (New York )
                ISSN (Print): 0938-8990
                ISSN (Electronic): 1432-1777
                Publication date (Electronic): 13 June 2017
                Publication date PMC-release: 13 June 2017
                Publication date (Print): 2017
                Volume: 28
                Issue: 7
                Pages: 315-323
                Affiliations
                ISNI 0000 0004 1936 7988, GRID grid.4305.2, The Roslin Institute and Royal Dick School of Veterinary Studies, , University of Edinburgh, ; Easter Bush Campus, Midlothian, EH25 9RG UK
                Article
                Publisher ID: 9701
                DOI: 10.1007/s00335-017-9701-z
                PMC ID: 5569130
                PubMed ID: 28612238
                SO-VID: 660fac5f-a675-4aa3-aafc-ca0fa5204d90
                Copyright © © The Author(s) 2017
                License:

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                Date received : 7 April 2017
                Date accepted : 5 June 2017
                Categories
                Subject: Article
                Custom metadata
                issue-copyright-statement © Springer Science+Business Media, LLC 2017

                ScienceOpen disciplines: Genetics
                Data availability:
                ScienceOpen disciplines: Genetics

                Comments

                Comment on this article

                scite_

                Similar content399

                See all similar

                Cited by18

                See all cited by

                Most referenced authors8,500

                See all reference authors