+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Acceleration training for managing nonalcoholic fatty liver disease: a pilot study

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.



          While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects.


          A total of 18 obese patients with NAFLD who had no improvement in liver function test abnormalities and/or steatosis grade after 12 weeks of lifestyle counseling were enrolled in an AT program. These patients attended a 20-minute session of AT twice a week for 12 consecutive weeks.


          During the AT program, the NAFLD patients showed a modest increase in the strength (+12.6%) and cross-sectional area (+3.1%) of the quadriceps, coupled with a significant reduction in intramyocellular lipids (−26.4%). Notably, they showed a modest reduction in body weight (−1.9%), abdominal visceral fat area (−3.4%), and hepatic fat content (−8.7%), coupled with a significant reduction in levels of aminotransferase (−15.7%), γ-glutamyltransferase (−14.4%), leptin (−9.7%), interleukin-6 (−26.8%), and tumor necrosis factor-α (−17.9%), and a significant increase of adiponectin (+8.7%). On a health-related quality of life survey, the patients showed an improvement in physical functioning (+17.3%), physical role (+9.7%), general health (+22.1), and social functioning (+6.0%).


          AT reduced hepatic and intramyocellular fat contents and ameliorated liver function test abnormalities in obese patients with NAFLD, which was coupled with improved physical function and body adiposity. AT is clinically beneficial for the management of NAFLD.

          Related collections

          Most cited references 20

          • Record: found
          • Abstract: found
          • Article: not found

          Vibration as an exercise modality: how it may work, and what its potential might be.

          Whilst exposure to vibration is traditionally regarded as perilous, recent research has focussed on potential benefits. Here, the physical principles of forced oscillations are discussed in relation to vibration as an exercise modality. Acute physiological responses to isolated tendon and muscle vibration and to whole body vibration exercise are reviewed, as well as the training effects upon the musculature, bone mineral density and posture. Possible applications in sports and medicine are discussed. Evidence suggests that acute vibration exercise seems to elicit a specific warm-up effect, and that vibration training seems to improve muscle power, although the potential benefits over traditional forms of resistive exercise are still unclear. Vibration training also seems to improve balance in sub-populations prone to fall, such as frail elderly people. Moreover, literature suggests that vibration is beneficial to reduce chronic lower back pain and other types of pain. Other future indications are perceivable.
            • Record: found
            • Abstract: found
            • Article: not found

            Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes.

            Strength training represents an alternative to endurance training for patients with type 2 diabetes. Little is known about the effect on insulin action and key proteins in skeletal muscle, and the necessary volume of strength training is unknown. A total of 10 type 2 diabetic subjects and 7 healthy men (control subjects) strength-trained one leg three times per week for 6 weeks while the other leg remained untrained. Each session lasted no more than 30 min. After strength training, muscle biopsies were obtained, and an isoglycemic-hyperinsulinemic clamp combined with arterio-femoral venous catheterization of both legs was carried out. In general, qualitatively similar responses were obtained in both groups. During the clamp, leg blood flow was higher (P < 0.05) in trained versus untrained legs, but despite this, arterio-venous extraction glucose did not decrease in trained legs. Thus, leg glucose clearance was increased in trained legs (P < 0.05) and more than explained by increases in muscle mass. Strength training increased protein content of GLUT4, insulin receptor, protein kinase B-alpha/beta, glycogen synthase (GS), and GS total activity. In conclusion, we found that strength training for 30 min three times per week increases insulin action in skeletal muscle in both groups. The adaptation is attributable to local contraction-mediated mechanisms involving key proteins in the insulin signaling cascade.
              • Record: found
              • Abstract: not found
              • Article: not found

              Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary.


                Author and article information

                Ther Clin Risk Manag
                Ther Clin Risk Manag
                Therapeutics and Clinical Risk Management
                Therapeutics and Clinical Risk Management
                Dove Medical Press
                07 November 2014
                : 10
                : 925-936
                [1 ]Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Ibaraki, Tokyo, Japan
                [2 ]Department of Rehabilitation, Tsukuba University Hospital, Ibaraki, Tokyo, Japan
                [3 ]Department of Diagnostic Radiology, University of Tsukuba, Ibaraki, Tokyo, Japan
                [4 ]Department of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Tokyo, Japan
                [5 ]Protea Japan Co Ltd, Chiyoda, Tokyo, Japan
                Author notes
                Correspondence: Junichi Shoda, Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan, Tel +81 29 853 5795, Fax +81 29 853 5795, Email shodaj@ 123456md.tsukuba.ac.jp
                © 2014 Oh et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

                The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                Original Research


                quality of life, whole-body vibration, obesity, liver steatosis, adipokine


                Comment on this article