0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity.

      Cell

      Activins, Amino Acid Sequence, Animals, Base Sequence, Central Nervous System, embryology, Cloning, Molecular, Embryo, Nonmammalian, physiology, Embryonic Induction, Follistatin, Gastrula, chemistry, Glycoproteins, analysis, genetics, Inhibins, antagonists & inhibitors, Mesoderm, Molecular Sequence Data, Notochord, Protein Biosynthesis, RNA, Messenger, Sequence Analysis, DNA, Xenopus laevis

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In the accompanying paper, we show that the expression of a dominant negative activin receptor can convert prospective ectoderm into neural tissue, which suggests that activin is an inhibitor of neuralization. Here we report the isolation and characterization of an activin antagonist, follistatin, that can induce neural tissue directly in vivo. Follistatin RNA is localized in the Spemann organizer and notochord, tissues known to be potent neural inducers. We demonstrate that follistatin RNA and protein are able to block the activity of activin in embryonic explants. Furthermore, we show that follistatin RNA directly neuralizes ectodermal explants in the absence of detectable mesoderm. Thus, follistatin is present at the correct time and location to play a role in neural induction in vivo.

          Related collections

          Author and article information

          Journal
          8168135

          Comments

          Comment on this article