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      Multiplication of neutrophil and monocyte counts (MNM) as an easily obtainable tumour marker for cervical cancer.

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          Abstract

          Simple, non-aversive methods to identify cervical neoplasia are needed. The purpose of this study was to investigate the clinical value of differential white blood cell (WBC) counts as a biomarker for cervical neoplasia. We performed a retrospective review of laboratory results in 407 cervical cancers, 495 cervical intraepithelial neoplasias (CIN) and 916 healthy controls. Because pretreatment neutrophil and monocyte counts showed the potential as a biomarker, we combined these parameters and designated this combined marker MNM (multiplication of neutrophil and monocyte counts). MNM showed a sensitivity of 53.1% and a specificity of 78.1%, which are much higher than those of SCC-Ag. On Cox multivariate analysis, MNM positivity (hazard ratio = 2.82, p = 0.042), stage and tumour size were independent predictors of poor prognosis. Our findings suggest that pretreatment MNM could be a candidate as a simple and cost-effective biomarker in cervical cancer.

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          Author and article information

          Journal
          Biomarkers
          Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
          Informa UK Limited
          1366-5804
          1354-750X
          May 2009
          : 14
          : 3
          Affiliations
          [1 ] Department of Obstetrics and Gynecology, Yongdong Severance Hospital, Yonsei University College of Medicine, 146-92 Dogok-Dong, Gangnam-Gu, Seoul, South Korea.
          Article
          910746123
          10.1080/13547500902777616
          19399661
          6634e9ee-d576-403d-a9c4-28fc219a4108
          History

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