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      Inflammatory myofibroblastic disease of right petrous apex: A rare case with review of literature

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          ABSTRACT

          Inflammatory myofibroblastic tumor (IMFT) is a rare tumor of unknown etiology. It can involve any part of the body. The IMFT involving the base of skull is rare with only 36 cases reported in the literature. We report a rare case of IMFT of temporal bone with review of literature. A 42 year old male presented with complaints of headache and double vision and MRI brain showed lesion in the right petrous apex region suggestive of a neurogenic mass. He had excision of lesion and histopathology was suggestive of IMFT with IgG4 and ALK positive. He had complete clinical response but a month later he presented with right eyelid ptosis and decreased rotation of eye medially with recurrent lesion on MRI. Patient received radiation by SRT technique and then started on Ceretinib with partial response. The IMFT is rare tumor of unknown etiology and tumors of temporal bone are more aggressive. It is benign but locally invasive tumor. Treatment of IMFT is controversial. Extensive surgery with complete excision has about 80% response rates and with intracranial extension, adjuvant radiation is need. In head and neck IMFT response rates are lower (30 to 40%). Monoclonal antibodies and steroids are used in IMFT at recurrence. In advanced or metastatic ALK positive tumors, Crizotinib is used with a response rate of 50%. Radiotherapy (25 to 30 Gy) induces remission and helps to taper the steroids. Temporal bone IMFT is a rare tumor with multimodality approach and variable response to treatment.

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          Author and article information

          Journal
          Journal of Cancer Research and Therapeutics
          Medknow
          0973-1482
          1998-4138
          January 22 2024
          Affiliations
          [1 ]Nuclear Medicine, King George Hospital, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India
          [2 ]Consultant Radiation Oncologist, Omega Hospital, Guntur, Andhra Pradesh, India
          [3 ]Department of Radiation Oncology, Mehdi Nawaz Jung Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India
          [4 ]Consultant Surgical Oncologist, Omega Hospital, Guntur, Andhra Pradesh, India
          Article
          10.4103/jcrt.JCRT_1451_20
          38261452
          664f45b2-6f2a-4bd9-a8a9-8d7449044854
          © 2024
          History

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