Kidney injury molecule-1 and the loss of kidney function in diabetic nephropathy: a likely causal link in patients with type 1 diabetes.

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Abstract

We evaluated the predictive value and clinical benefit of urinary kidney injury molecule (KIM)-1 for progression of diabetic nephropathy (DN) in type 1 diabetes. We also investigated its causal role for the decrease of estimated glomerular filtration rate (eGFR) by a Mendelian randomization (MR) approach.

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Author and article information

Journal

Journal ID (iso-abbrev): Diabetes Care

Title: Diabetes care

ISSN (Electronic): 1935-5548

ISSN (Print): 0149-5992

Publication date (Electronic): Jun 2015

Volume: 38

Issue: 6

Affiliations

[1 ] 2nd Clinical Department, Diabetes Nutrition and Metabolic Diseases Chair, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

[2 ] Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

[3 ] Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.

[4 ] Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany.

[5 ] Stoffwechselzentrum Rhein Pfalz, Mannheim, Germany.

[6 ] Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia per-henrik.groop@helsinki.fi.

Article

Publisher Item ID: dc14-2330

DOI: 10.2337/dc14-2330

PubMed ID: 25784666

SO-VID: 6653bf67-062a-43a8-b66f-c13e0bfd5bb7

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