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Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
Raquel Pereira ,
Claudine Gaudon ,
Beatriz Iglesias ,
Pierre Germain ,
Hinrich Gronemeyer ,
Angel R. de Lera
January 2006
January 2006
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Abstract
Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole
provided the scaffold for the synthesis of GW501516, the most potent PPARbeta/delta
agonist yet described, and equally selective analogs at the thiazole-C4 position.