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      Hypersensitivity of the Human Gonadotrophs to the Repeated Administration of Small Doses of LH-RH


      Hormone Research in Paediatrics

      S. Karger AG

      Gonadotrophins, Menstrual cycle, LH-RH

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          The functional capacity of the gonadotrophs was assessed by repeated stimulation with small doses of LH-RH (5 µg intravenously at 2-hour intervals for 3 injections) in normal women during the early and late follicular phases of the menstrual cycle. The results were compared to those obtained when a single large dose (100 µg) of the neurohormone was administered. During the early follicular phase, the release of LH and FSH remained about equal after the 3 successive injections of the small and after the large dose of LH-RH. During the late follicular phase, the release of LH and FSH increased progressively after the repeated administration of the 5 µg dose of the neurohormone while the large dose induced a more pronounced and a more sustained pituitary response. This hypersensitivity of the gonadotrophs is observed when the E<sub>2</sub> concentrations are higher than in the early follicular phase of the menstrual cycle.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 9
          : 1
          : 12-21
          Laboratoires de Recherche en Endocrinologie et Métabolisme, Centre Hospitalier de l’Université, Laval, Qué.
          178892 Horm Res 1978;9:12–21
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 10


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