Schmidt Syndrome in Pregnancy: A Hormonal Potpourri to a Happy Pregnancy

ABSTRACT

Autoimmune polyglandular syndrome type 2 (APS-2) or Schmidt syndrome is defined as a coexistence of autoimmune thyroid disease, primary adrenal insufficiency, and/or type 1 diabetes mellitus. The presentation of APS-2 is rarely encountered during pregnancy since there is reduced fertility owing to the adrenal and thyroid insufficiency individually and can present with multiple complications. We present a case of a 25-year-old G2A1, who is a known case of Schmidt syndrome diagnosed preconceptionally when presented with nausea, vomiting, diffuse and progressive hyperpigmentation spots over palmar creases, soles with elevated ACTH and decreased level of cortisol, and resolution of symptoms when started on steroid replacement therapy. The patient was followed up regularly throughout the pregnancy and delivered by cesarean section and developed gestational hypertension, which was treated. We present this case to conclude that pregnancy with Addison's disease can be managed successfully with proper monitoring and multidisciplinary management approach.

How to cite this article

Vilashini V, Rohini G, Senathirajah T. Schmidt Syndrome in Pregnancy: A Hormonal Potpourri to a Happy Pregnancy. J South Asian Feder Obst Gynae 2023;15(3):332–334.