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      Effects of Uptake and Surface of Entry on the Responses of the Rat Caudal Artery to Noradrenaline, Adrenaline and Methoxamine

      research-article
      ,
      Journal of Vascular Research
      S. Karger AG
      Rat tail artery, Catecholamines, Methoxamine, Cocaine, DOCA

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          Abstract

          The action of adrenaline on the rat tail artery was similar to that of noradrenaline in that (i) adrenaline was more potent by the intraluminal than the extraluminal route of application, and (ii) cocaine eliminated the difference in potency by selectively enhancing the response to extraluminal adrenaline. In the absence of cocaine, extraluminal adrenaline was more potent than extraluminal noradrenaline; in the presence of cocaine, the two amines were equipotent, irrespective of the route of application. The intraluminal and extraluminal potencies of methoxamine did not differ, either in the absence or presence of cocaine. It is concluded that neuronal uptake is responsible for differences between the potencies of noradrenaline and adrenaline and for the effect of the route of applications on these potencies. Potentiation of responses to both noradrenaline and adrenaline by 27 µ M deoxycorticosterone acetate was minor compared with that by cocaine. The results provide further evidence that in the rat tail artery the extraneuronal uptake system is poorly developed compared with the neuronal uptake system.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1984
          1984
          23 September 2008
          : 21
          : 4
          : 149-155
          Affiliations
          Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia
          Article
          158507 Blood Vessels 1984;21:149–155
          10.1159/000158507
          668a2dd6-a11a-4f32-b0b2-e341137d33fd
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 10 September 1981
          : 22 August 1983
          Page count
          Pages: 7
          Categories
          Research Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Methoxamine,Rat tail artery,DOCA,Catecholamines,Cocaine

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