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      Early Hybrid Extracorporeal Therapies in Pediatric Acute Liver Failure of Unknown Etiology

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          We describe a 9-year-old boy with acute liver failure of unknown etiology, unresponsive to standard medical therapy, with increasing hyperammonemia blood level, lactate elevation, a pediatric end liver stage of 20, a hepatic encephalopathy (HE) score of 2, and scheduled for emergent liver transplantation on the waiting list. We admitted him in the pediatric intensive care unit and managed him in the early stages with continuous renal replacement therapy and therapeutic plasma exchange as soon as neurologic impairment started to worsen. He recovered from his HE after 3 days of blood purification and was removed from the transplantation waiting list due to progressive liver function improvement.

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          Author and article information

          Blood Purif
          Blood Purification
          S. Karger AG
          May 2020
          07 January 2020
          : 49
          : 3
          : 382-384
          Department of Emergency, Anaesthesia and Intensive Care Unit, Bambino Gesù Children’s Hospital, Rome, Italy
          Author notes
          *Emanuele Rossetti, Department of Emergency, Anaesthesia and Intensive Care Unit, Bambino Gesù Children’s Hospital, Piazza S. Onofrio 4, IT–00165 Rome (Italy), E-Mail emanuele.rossetti@opbg.net
          504559 Blood Purif 2020;49:382–384
          © 2020 S. Karger AG, Basel

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          Figures: 1, Tables: 1, Pages: 3
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