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      Comparative study of fourteen alkaloids from Uncaria rhynchophylla hooks and leaves using HPLC-diode array detection-atmospheric pressure chemical ionization/MS method.

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          Abstract

          The purpose of the study is to compare alkaloid profile of Uncaria rhynchophylla hooks and leaves. Ten oxindole alkaloids and four glycosidic indole alkaloids were identified using HPLC-diode array detection (DAD) or LC-atmospheric pressure chemical ionization (APCI)-MS method, and a HPLC-UV method for simultaneous quantification of major alkaloids was validated. The hooks are characterized by high levels of four oxindole alkaloids rhynchophylline (R), isorhynchophylline (IR), corynoxeine (C) and isocorynoxeine (IC), while the leaves contained high level of two glycosidic indole alkaloids vincoside lactam (VL) and strictosidine (S). The presented methods have proven its usefulness in chemical characterization of U. rhynchophylla hooks and leaves.

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          Author and article information

          Journal
          Chem. Pharm. Bull.
          Chemical & pharmaceutical bulletin
          1347-5223
          0009-2363
          2012
          : 60
          : 1
          Affiliations
          [1 ] School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China.
          Article
          JST.JSTAGE/cpb/60.23
          22223371

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