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      ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.


      Amino Acid Sequence, Animals, Ankyrins, chemistry, CHO Cells, Calcium Channels, metabolism, Capsaicin, pharmacology, Cells, Cultured, Cold Temperature, Cricetinae, Female, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Afferent, Nociceptors, Protein Structure, Tertiary, Rats, Rats, Sprague-Dawley, TRPC Cation Channels, Thermoreceptors, Transient Receptor Potential Channels

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          Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

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