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      Magnetic Resonance Techniques for Assessment of Body Components

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          Abstract

          With the increasing interest in personal health, nutritional status and fitness, several methods of estimating body fat have been developed and used in clinical settings. Hormonal effects and changes in metabolic pathways during the development of diseases (e.g. type 2 diabetes mellitus) lead to specific changes in the volume fractions and distribution of fat-containing compartments in the body. Magnetic resonance (MR) has been proven to be a reliable and non-invasive tool for the assessment of fatty and lean tissue, with a high spatial resolution of approximately 1 mm. Modern MR systems with large receiver coil arrays and automatic positioning tables allow whole-body imaging in examination times of about 20 min. Special highly specific fat-selective imaging techniques provide total suppression of water signals and allow a sensitive visualization of fatty infiltration in ‘lean’ organs, such as liver or skeletal musculature. Whereas fat-selective imaging requires at least 1–2% of lipids in parenchymal tissue to provide signal intensity in the images above the noise level, volume-selective [<sup>1</sup>H]MR spectroscopy is even more sensitive. Volume fractions of lipids down to 0.1% can be quantitatively assessed using [<sup>1</sup>H]MR spectroscopy, and several portions of lipids (fatty septa vs. intramyocellular fat) can be distinguished in skeletal musculature.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-8244-5
          978-3-318-01440-2
          1663-2818
          1663-2826
          2006
          January 2007
          25 January 2007
          : 66
          : Suppl 1
          : 65-72
          Affiliations
          aExperimental Radiology Section, Department of Diagnostic Radiology, and bDepartment of Internal Medicine, University of Tübingen, Tübingen, Germany
          Article
          96625 Horm Res 2006;66:65–72
          10.1159/000096625
          © 2006 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 3, References: 25, Pages: 8
          Categories
          Validity of Methods Used for the Assessment of Body Components in Children

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