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      Reduced Pituitary Volume in Children with Short Stature: Clinical and Radiological Correlates

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      Hormone Research in Paediatrics

      S. Karger AG

      Pituitary gland, CT scan, Short stature, Growth hormone

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          A retrospective evaluation of 80 cases of growth retardation evaluated at the Hôpital Sainte-Justine of Montreal has revealed that 20 of them (25 %; 15 boys and 5 girls) had a reduction of pituitary volume as revealed by high-resolution CT scanning of the pituitary gland. Of these patients, 8 had complete growth hormone (GH) deficiency, as evaluated by arginine infusion and L-Dopa-propranolol testing and nocturnal blood sampling, and 3 had GH neurosecretory dysfunction. Five patients had combined or multiple hormonal deficiencies. A statistically significant correlation was found between nocturnal plasma GH values and pituitary volumes. From this study it can be concluded that reduced pituitary volume is a frequent finding in growth-retarded children with hypopituitarism.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 32
          : 4
          : 113-118
          Service of Endocrinology, Department of Pediatrics, and Department of Radiology, Hôpital Sainte-Justine, Université de Montréal, Montréal, Que., Canada
          181271 Horm Res 1989;32:113–118
          © 1989 S. Karger AG, Basel

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          Pages: 6
          Original Paper


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