10
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Chronic Treatment with Minoxidil Induces Elastic Fiber Neosynthesis and Functional Improvement in the Aorta of Aged Mice.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Normal arterial aging processes involve vascular cell dysfunction associated with wall stiffening, the latter being due to progressive elastin and elastic fiber degradation, and elastin and collagen cross-linking by advanced glycation end products (AGEs). These processes progressively lead to cardiovascular dysfunction during aging. Elastin is only synthesized during late gestation and childhood, and further degradation occurring throughout adulthood cannot be physiologically compensated by replacement of altered material. However, the ATP-dependent K+channel opener minoxidil has been shown to stimulate elastin expression in vitro and in vivo in the aorta of young adult rats. Therefore, we have studied the effect of a 10-week chronic oral treatment with minoxidil (120 mg/L in drinking water) on the aortic structure and function in aged 24-month-old mice. Minoxidil treatment increased tropoelastin, fibulin-5, and lysyl-oxidase messenger RNA levels, reinduced a moderate expression of elastin, and lowered the levels of AGE-related molecules. This was accompanied by the formation of newly synthesized elastic fibers, which had diverse orientations in the wall. A decrease in the glycation capacity of aortic elastin was also produced by minoxidil treatment. The ascending aorta also underwent a minoxidil-induced increase in diameter and decrease in wall thickness, which partly reversed the age-associated thickening and returned the wall thickness value and strain-stress relation closer to those of younger adult animals. In conclusion, our results suggest that minoxidil presents an interesting potential for arterial remodeling in an antiaging perspective, even when treating already aged animals.

          Related collections

          Author and article information

          Journal
          Rejuvenation Res
          Rejuvenation research
          Mary Ann Liebert Inc
          1557-8577
          1549-1684
          Jun 2017
          : 20
          : 3
          Affiliations
          [1 ] 1 PVICSV-INSERM U882-iRTSV-CEA, Université Joseph Fourier , Grenoble, France .
          [2 ] 2 INSERM, U1148, and Hôpital Bichat-Claude Bernard , Paris, France .
          [3 ] 3 Université Grenoble Alpes , HP2, Grenoble, France .
          [4 ] 4 INSERM U1042 , HP2, Grenoble, France .
          [5 ] 5 CHU de Grenoble , HP2, Grenoble, France .
          [6 ] 6 Departments of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain; Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain .
          [7 ] 7 Medical University of Pleven, Department of Biology, Pleven, Bulgaria .
          [8 ] 8 BCI-BPCR-INSERM UMR_S1036-iRTSV-CEA, Université Grenoble Alpes , Grenoble, France .
          [9 ] 9 IBS Platform of the Grenoble Instruct Center (ISBG: UMS 3518 CNRS-CEA- Université Grenoble Alpes -EMBL), Grenoble, France .
          Article
          10.1089/rej.2016.1874
          28056723
          66ef95b0-2799-4f13-989a-6adecc9428f9
          History

          minoxidil,advanced glycation end products,aging,arteries,elastin,mechanics

          Comments

          Comment on this article