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Initial Evaluation of [(18)F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer.
Zsolt Szabo
1 ,
Esther Mena ,
Steven P Rowe ,
Donika Plyku ,
Rosa Nidal ,
Mario A Eisenberger ,
Emmanuel S Antonarakis ,
Hong Fan ,
Robert F Dannals ,
Ying Chen ,
Ronnie C Mease ,
Melin Vranesic ,
Akrita Bhatnagar ,
George Sgouros ,
Steve Y Cho ,
Martin G Pomper
Aug 2015
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Abstract
Prostate-specific membrane antigen (PSMA) is a recognized target for imaging prostate cancer. Here we present initial safety, biodistribution, and radiation dosimetry results with [(18)F]DCFPyL, a second-generation fluorine-18-labeled small-molecule PSMA inhibitor, in patients with prostate cancer.