ERK1/2 MAP kinases in cell survival and apoptosis.

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Abstract

ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions.

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Journal

Journal ID (iso-abbrev): IUBMB Life

Title: IUBMB life

Publisher: Informa UK Limited

ISSN: 1521-6543

ISSN (Print): 1521-6543

Publication date (Electronic): Nov 2006

Volume: 58

Issue: 11

Affiliations

[1 ] Brain Tumor Center and Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030, USA. zhiminlu@mdanderson.org

Article

Publisher Item ID: NK321200M08H4W61

DOI: 10.1080/15216540600957438

PubMed ID: 17085381

SO-VID: 66f149b0-5107-4b05-b689-474578ac539a

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