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      Neural Regulation of TSH Secretion: Thyroxine Feedback in the Newborn

      ,

      Neuroendocrinology

      S. Karger AG

      TSH secretion, Newborn, Hypothalamus, Preoptic area, Thyroxine feedback, Deafferentation

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          Abstract

          Responses to hemithyroidectomy and thyroxine treatment were examined in normal kittens 5–21 days of age and in kittens in which the basal hypothalamus was deafferented. After hemithyroidectomy on the 5th day, the remaining thyroid lobe exhibits no compensatory increases in weight or <sup>131</sup>I uptake. Deafferentation at 5–6 days of age evokes a marked increase in gland weight during the next 15 days. Treatment with thyroxine (0.25–5.0 µg/kg/day) for 15 days causes an almost 3-fold increase in gland weight, and high PBI levels. Thyroxine: cholesterol pellets that had no effect subcutaneously markedly stimulated gland weight when implanted in the preoptic area of the hypothalamus. It is concluded that, as in adult cats, the preoptic area of the hypothalamus in kittens contains an inhibiting neural pathway associated with regulation of TSH secretion, but that the relevant neurone pools in this area of newborn and adult cat brains respond to thyroxine in opposite manners.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1972
          1972
          19 March 2008
          : 10
          : 4
          : 197-206
          Affiliations
          Department of Anatomy, University of Rochester, School of Medicine and Dentistry, Rochester, New York
          Article
          122089 Neuroendocrinology 1972;10:197–206
          10.1159/000122089
          4653503
          © 1972 S. Karger AG, Basel

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          Page count
          Pages: 10
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