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      Cellular and molecular mechanisms of drug dependence.

      1 ,
      Science (New York, N.Y.)
      American Association for the Advancement of Science (AAAS)

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          Abstract

          The molecular and cellular actions of three classes of abused drugs--opiates, psychostimulants, and ethanol--are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are compared to those observed after long-term exposure. A neurobiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Nov 04 1988
          : 242
          : 4879
          Affiliations
          [1 ] Research Institute of Scripps Clinic, La Jolla, CA 92037.
          Article
          10.1126/science.2903550
          2903550
          66f9f747-fc41-467e-af1f-2f2e3eb9cd81
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