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      Changes in Phosphorus Excretion and Renal Function After Human Renal Homotransplantation

      , , , ,

      Nephron

      S. Karger AG

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          Abstract

          Early physiological studies of 12 human renal homografts and comparison of 5 of these with their pre-transplant function in the donor and the post-transplant function of the remaining donor kidney have demonstrated that the transplantation process causes a striking reduction in filtration fraction stemming from a disproportionate decrease in GFR. Studies of TRP in these 12 patients, amino acid clearances in 5 patients, and response to calcium infusion in 7 patients have been done in an attempt to gather further information on phosphorus exretion and parathyroid function in human homotransplantation. It has been concluded that some degree of autonomicity of parathyroid secretion is seen after human renal homotransplantation and that abnormalities of proximal tubular function contribute to unusual degrees of phosphorus excretion. Long term follow-up of 4 patients with well tolerated renal homografts indicated remarkable stability of GFR, RPF, and TRP once a graft is well established in its new host.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1968
          1968
          26 November 2008
          : 5
          : 3
          : 170-184
          Affiliations
          University of Minnesota, Minneapolis, Minn.
          Article
          179628 Nephron 1968;5:170–184
          10.1159/000179628
          4876293
          © 1968 S. Karger AG, Basel

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          Page count
          Pages: 15
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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