Changes in Phosphorus Excretion and Renal Function After Human Renal Homotransplantation

Abstract

Early physiological studies of 12 human renal homografts and comparison of 5 of these with their pre-transplant function in the donor and the post-transplant function of the remaining donor kidney have demonstrated that the transplantation process causes a striking reduction in filtration fraction stemming from a disproportionate decrease in GFR. Studies of TRP in these 12 patients, amino acid clearances in 5 patients, and response to calcium infusion in 7 patients have been done in an attempt to gather further information on phosphorus exretion and parathyroid function in human homotransplantation. It has been concluded that some degree of autonomicity of parathyroid secretion is seen after human renal homotransplantation and that abnormalities of proximal tubular function contribute to unusual degrees of phosphorus excretion. Long term follow-up of 4 patients with well tolerated renal homografts indicated remarkable stability of GFR, RPF, and TRP once a graft is well established in its new host.