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      Dynamics of stability: the physiologic basis of functional health and frailty.

      The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
      Aged, Aged, 80 and over, Aging, physiology, Frail Elderly, Health, Humans, Nonlinear Dynamics

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          Abstract

          Under basal resting conditions most healthy physiologic systems demonstrate highly irregular, complex dynamics that represent interacting regulatory processes operating over multiple time scales. These processes prime the organism for an adaptive response, making it ready and able to react to sudden physiologic stresses. When the organism is perturbed or deviates from a given set of boundary conditions, most physiologic systems evoke closed-loop responses that operate over relatively short periods of time to restore the organism to equilibrium. This transiently alters the dynamics to a less complex, dominant response mode, which is denoted "reactive tuning." Aging and disease are associated with a loss of complexity in resting dynamics and maladaptive responses to perturbations. These alterations in the dynamics of physiologic systems lead to functional decline and frailty. Nonlinear mathematical techniques that quantify physiologic dynamics may predict the onset of frailty, and interventions aimed toward restoring healthy dynamics may prevent functional decline.

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          Author and article information

          Journal
          11867648
          10.1093/gerona/57.3.b115

          Chemistry
          Aged,Aged, 80 and over,Aging,physiology,Frail Elderly,Health,Humans,Nonlinear Dynamics
          Chemistry
          Aged, Aged, 80 and over, Aging, physiology, Frail Elderly, Health, Humans, Nonlinear Dynamics

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