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      Prevalence of Autoantibodies to Endocrine Organs in Girls with Ullrich-Turner Syndrome Aged 5-14 Years

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          Abstract

          Endocrine function tests and a broad panel of autoantibodies to endocrine organs were assessed in 77 patients aged 5-14 years with Ullrich-Turner syndrome (UTS), who were included in the German UTS Multicenter Study. None of these patients had abnormal pituitary, thyroid or adrenocortical function, as assessed by the adequate hormone tests. Antibodies to thyroid microsomes were found in 3 of the 77 (3.9%), antibodies to thyroglobulin in 0/77, antibodies to adrenocortical cells in 1/77 (1.3%), gastric parietal cell antibodies in 2/77 (2.6%), and anterior pituitary cell antibodies in 3/77 (3.9%) probands. These prevalences were not significantly higher than those obtained in 154 age- and sex-matched normal control children when 2 control subjects were assigned to each patient with UTS. Our data do not show an increase in serological signs of endocrine autoimmunity in young patients with UTS suggesting that a putative association of these syndromes does not exist from birth and is not usually present in childhood. However, we cannot exclude the possibility that UTS is associated with factors that render these patients more susceptible to endocrine autoimmunity later in life.

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          Author and article information

          Journal
          HRE
          10.1159/issn.0018-5051
          Hormone Research in Paediatrics
          S. Karger AG
          0018-5051
          2571-6603
          1992
          1992
          03 December 2008
          : 38
          : 3-4
          : 114-119
          Affiliations
          aDepartment of Internal Medicine, Medical Clinic and Polyclinic, University of Ulm and bUTS Multicenter Study Group, Bad Homburg, FRG
          Article
          182525 Horm Res 1992;38:114–119
          10.1159/000182525
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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