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      Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases.

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          Abstract

          This review examines the pharmacokinetics, modes of action and therapeutic properties of the anti-malarial drugs, hydroxychloroquine (HCQ) and chloroquine (CQ), in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and related conditions, as well as osteoarthritis (OA).

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Inflammopharmacology
          Title: Inflammopharmacology
          Publisher: Springer Nature
          ISSN (Electronic): 1568-5608
          ISSN (Print): 0925-4692
          Publication date (Electronic): Oct 2015
          Volume: 23
          Issue: 5
          Affiliations
          [1 ] Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK.
          [2 ] Department of Rheumatology, St Francis Hospital and Medical Center, Hartford, CT, 06105, USA.
          [3 ] McMaster University, Hamilton, ON, L8S 4K9, Canada.
          [4 ] Department of Medicine (Rheumatology), McMaster University Faculty of Health Sciences, Hamilton, ON, L8S 4K9, Canada. keanmac@cogeco.ca.
          [5 ] Department of Medicine (Rheumatology), McMaster University Faculty of Health Sciences, Suite #708, 1 Young Street, Hamilton, ON, L8N 1T8, Canada. keanmac@cogeco.ca.
          Article
          Publisher Item ID: 10.1007/s10787-015-0239-y
          DOI: 10.1007/s10787-015-0239-y
          PubMed ID: 26246395
          SO-VID: 671ac997-cf2f-42c2-8ac6-3d7a88d50685
          History

          Keywords: Chloroquine,Chronic inflammation,Cytokine,Dermatological,Hydroxychloroquine,Inflammasome,Lupus,Lysosomotropic activity,Rheumatoid arthritis,Sjøgren’s syndrome,Toll-like receptors
          Data availability:
          Keywords: Chloroquine, Chronic inflammation, Cytokine, Dermatological, Hydroxychloroquine, Inflammasome, Lupus, Lysosomotropic activity, Rheumatoid arthritis, Sjøgren’s syndrome, Toll-like receptors

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