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      Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor-2.

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          Abstract

          Although biglycan (BGN) and oxidized low-density lipoprotein (oxLDL) accumulation has been observed in calcific, stenotic aortic valves, their role in the pathogenesis of calcific aortic valve disease is poorly understood. We hypothesized that soluble BGN induces the osteogenic response in human aortic valve interstitial cells via Toll-like receptor (TLR) 2 and TLR4 and mediates the proosteogenic effect of oxLDL.

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          Author and article information

          Journal
          Arterioscler Thromb Vasc Biol
          Arteriosclerosis, thrombosis, and vascular biology
          Ovid Technologies (Wolters Kluwer Health)
          1524-4636
          1079-5642
          Nov 2012
          : 32
          : 11
          Affiliations
          [1 ] Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USA.
          Article
          NIHMS411792 ATVBAHA.112.300116
          10.1161/ATVBAHA.112.300116
          3665416
          22982459
          6741bcf0-9ea7-4c08-8a55-fdfdd3980f5a
          History

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