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      Mosquito carboxylesterases: a review of the molecular biology and biochemistry of a major insecticide resistance mechanism.

        1 ,
      Medical and veterinary entomology
      Wiley

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          Abstract

          The major mechanism of organophosphorus insecticide resistance in Culex mosquitoes involves the elevation of one or more esterases. The general mechanism underlying this resistance is the amplification of the structural genes. This review covers the classification of the mosquito esterases in the context of classical esterase nomenclature. The function of the amplified esterases and the structure of the amplified DNA on which they occur are also described. Implications of information on the esterase amplicons are discussed in relation to the evolution and migration of insecticide resistance in Culex.

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          Author and article information

          Journal
          Med Vet Entomol
          Medical and veterinary entomology
          Wiley
          0269-283X
          0269-283X
          Jan 1998
          : 12
          : 1
          Affiliations
          [1 ] School of Pure and Applied Biology, University of Wales, Cardiff, U.K. Hemingway@cardiff.ac.uk
          Article
          10.1046/j.1365-2915.1998.00082.x
          9513933
          67482ff9-19e6-4213-b677-7f5ace6a42a2
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