The purpose of this study was to prepare proniosomal vesicles of Telmisartan (TEL) to be compressed into tablets which will be further evaluated in vitro and in vivo.
An experimental design was adopted using surfactants of different HLB values (span 40-brij 35), different cholesterol ratios (20–50%) and different phospholipid types (egg yolk-soyabean). Different responses were measured followed by tablet manufacturing. The highest EE was shown in F3 (85%) while the lowest value was obtained in F7 (8.4%). Finally, zeta potential results were in the range of −0.67 to −27.6 mv. Compressibility percent revealed that F5 showed an excellent flowability characteristic with a value of 9.74±1.61 while F3 and F6 showed good flowability characteristics. By the end of the release, F6 showed approximately 90% drug release.
F6 was selected for the in vivo study; C max was increased by 1.5-fold while AUC 0-∞ also increased significantly by 3-fold when compared with commercial tablet and finally, t max was increased by 3-fold indicating sustained release pattern. The relative bioavailability was also increased by 3.2-fold.