Jochen Huehn 1 , Kerstin Siegmund 1 , Joachim C.U. Lehmann 1 , Christiane Siewert 1 , Uta Haubold 1 , Markus Feuerer 1 , Gudrun F. Debes 1 , Joerg Lauber 2 , Oliver Frey 3 , Grzegorz K. Przybylski 4 , 5 , Uwe Niesner 6 , Maurus de la Rosa 6 , Christian A. Schmidt 4 , Rolf Bräuer 3 , Jan Buer 2 , Alexander Scheffold 6 , Alf Hamann 1
2 February 2004
Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin α Eβ 7 discriminates distinct subsets of murine CD4 + regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. α E −CD25 + cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, α E-positive subsets (CD25 + and CD25 −) displayed an effector/memory phenotype expressing high levels of E/P-selectin–binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, α E-expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.