Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date Collection: 2015
Publication date
(Electronic):
20
January
2015
Volume: 10
Issue: 1
Electronic Location Identifier: e0117098
Affiliations
[1
]Cardiovascular Research Center and Cardiology Division of the Department of Medicine,
Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
of America
[2
]Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical
Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston,
MA, United States of America
[3
]Department of Anesthesiology, Uniklinik Aachen, RWTH Aachen University, Aachen, Germany
[4
]Acceleron Pharma, Inc. Cambridge, MA, United States of America
[5
]Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston,
MA, United States of America
[6
]Center for Immunology and Inflammatory Diseases and the Division of Rheumatology,
Allergy, and Immunology of the Department of Medicine, Massachusetts General Hospital,
Harvard Medical School, Boston, MA, United States of America
Brigham and Women’s Hospital, Harvard Medical School, UNITED STATES
Author notes
Competing Interests: Dr. Ravindra Kumar is an employee of Acceleron Pharma Inc. and has stock ownership
in the company. This does not alter the authors’ adherence to PLOS ONE policies on
sharing data and materials. The Massachusetts General Hospital has applied for patents
related to pharmacologic BMP signaling inhibitors. These patents include: 1. Inhibitors
of the bmp signaling pathway (Application # CA 2718403, PCT/US2009/001606). Drs. Yu
and K. Bloch may be entitled to royalties. 2. Compositions and methods for cardiovascular
disease (Application # PCT/US2012/022119). Drs. Malhotra, Derwall, Yu, and K. Bloch
may be entitled to royalties. 3. Bmp inhibitors and methods of use thereof (Application
# PCT/US2014/020360). Drs. Yu and K. Bloch may be entitled to royalties. These patents
do not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: RM MFB TM HRS MD ESB PBY KDB DBB. Performed
the experiments: RM MFB TM HRS TET CO PL MD ES SAK KH CM PJ. Analyzed the data: RM
MFB TM HRS TET CO. Contributed reagents/materials/analysis tools: RM RK PBY KDB DBB.
Wrote the paper: RM MFB TM HRS TET CO PL MD ES SAK KH CM PJ RK ESB PBY KDB DBB.
Article
Publisher ID:
PONE-D-14-43227
DOI: 10.1371/journal.pone.0117098
PMC ID: 4300181
PubMed ID: 25603410
SO-VID: 6784ead1-0de0-4de9-8fcb-aab2d6be7324
Copyright statement:
Copyright @
2015
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited
This work was supported by the American Heart Association Fellow-to-Faculty Award
#11FTF7290032 (RM); the National Heart, Lung, and Blood Institute (K08HL111210, RM);
the Howard Hughes Medical Institute (TM and PJ); the Sarnoff Cardiovascular Research
Foundation (MFB and TET); the START-Program of the Faculty of Medicine at RWTH Aachen
(MD); the Leducq Foundation (Multidisciplinary Program to Elucidate the Role of Bone
Morphogenetic Protein Signaling in the Pathogenesis of Pulmonary and Systemic Vascular
Diseases, PBY and KDB); the National Institute of Arthritis and Musculoskeletal and
Skin Diseases (R01AR057374, PBY); and the National Institute of Diabetes and Digestive
and Kidney Diseases (R01DK082971, KDB). The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the manuscript.