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In auditory fear conditioning, repeated presentation of the tone in the absence of
the shock leads to extinction of the acquired fear response. Both the medial prefrontal
cortex (mPFC) and the basolateral amygdala (BLA) are involved in extinction. Here
we examined this involvement by antagonizing D1 receptors in both regions, in the
rat. We microinfused the D1 receptor antagonist, SCH23390, into the infra-limbic part
of the mPFC (IL) or BLA at different time points. SCH23390 mircoinfused into the IL
either before extinction acquisition or following short extinction training resulted
in impairment of extinction consolidation. Microinfusion of SCH23390 into the BLA,
prior to acquisition of extinction caused impairment in acquisition of extinction
without affecting extinction consolidation. This is supported by the results showing
that microinfusion of SCH23390 into the BLA following a short-training session did
not affect consolidation. These results further strengthen the role of mPFC in consolidation
of extinction while highlighting the role of the D1 receptors in this process.