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      Carboplatin hypersensitivity: a 6-h 12-step protocol effective in 35 desensitizations in patients with gynecological malignancies and mast cell/IgE-mediated reactions.

      1 , ,

      Gynecologic oncology

      Elsevier BV

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          Abstract

          The incidence of hypersensitivity reactions (HR) is increased in patients treated with multiple courses of carboplatin. The purposes of this investigation were to evaluate the effectiveness of a 12-step desensitization protocol and to characterize the immune mechanism of carboplatin HR.

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          Author and article information

          Journal
          Gynecol. Oncol.
          Gynecologic oncology
          Elsevier BV
          0090-8258
          0090-8258
          Nov 2004
          : 95
          : 2
          Affiliations
          [1 ] Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
          Article
          S0090-8258(04)00612-2
          10.1016/j.ygyno.2004.08.002
          15491759

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