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      Ultraviolet Filter Photography to Demonstrate the Fluorescence of Animal Lenses with Different Cataract Models

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          Ultraviolet (UV) filter photography with the Topcon SL-45 Scheimpfiug camera has provided valuable informations about age-related and cataract-type-dependent changes in the spectral properties of the human lens. The present study deals with the same phenomenon in normal lenses of the Brown-Norway rat and in those with true diabetic and naphthalene cataracts. The lenses of all animals of the 3 groups were photographed at the middle and final examination of a 6-week experiment on Kodak Tri-X-pan ASA 400 black-and-white film, using visible light (xenon flash) and UV-fütered light (320–390 nm transmission) from the same light source for recording. The results clearly demonstrate that both cataract models exhibit characteristic fluorescence properties, different from each other and from normal rat lenses. The naphthalene cataract shows the most drastic increase in fluorescence in the cortex, compared to the increase in scattering with visible light. The versatility of the method in preclinical research and the versatility of the cataract models open new aspects of drug-related research in drug toxicity studies.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          10 December 2009
          : 22
          : Suppl 1
          : 56-61
          Department of Experimental Ophthalmology, University of Bonn, FRG
          267066 Ophthalmic Res 1990;22:56–61
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 6
          Classification, Monitoring and Evaluation of Cataracts


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