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      Modulation of the Action of Calcium Antagonists in Arteries

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          This paper is a review of the experimental evidence showing that specific binding sites for dihydropyridine Ca antagonists are involved in inhibition of stimulus-dependent Ca entry into arterial cells and thereby in inhibition of the contractile response. The apparent affinity of the dihydropyridine binding site is related to the proportion of a high- and a low-affinity state which is regulated by membrane potential but could also be dependent upon other factors such as G proteins. Among Ca antagonists, a subgroup of agents exhibiting voltage dependence may be identified. Their apparent pharmacological potency is highly dependent on resting membrane potential and on the duration of the depolarizing stimulus.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 27
          : 2-5
          : 184-196
          Laboratoire de Pharmacodynamie Générate et de Pharmacologie, Université Catholique de Louvain, Bruxelles, Belgique
          158809 Blood Vessels 1990;27:184–196
          © 1990 S. Karger AG, Basel

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          Pages: 13
          Mechanisms of Vasodilatation


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