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      The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration.

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          Abstract

          The unique properties of mesenchymal stromal/stem cells (MSCs) to self-renew and their multipotentiality have rendered them attractive to researchers and clinicians. In addition to the differentiation potential, the broad repertoire of secreted trophic factors (cytokines) exhibiting diverse functions such as immunomodulation, anti-inflammatory activity, angiogenesis and anti-apoptotic, commonly referred to as the MSC secretome, has gained immense attention in the past few years. There is enough evidence to show that the one important pathway by which MSCs participate in tissue repair and regeneration is through its secretome. Concurrently, a large body of MSC research has focused on characterization of the MSC secretome; this includes both soluble factors and factors released in extracellular vesicles, for example, exosomes and microvesicles. This review provides an overview of our current understanding of the MSC secretome with respect to their potential clinical applications.

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          Author and article information

          Journal
          Cytotherapy
          Cytotherapy
          1477-2566
          1465-3249
          Jan 2016
          : 18
          : 1
          Affiliations
          [1 ] Department of Marine Biotechnology, AMET University, Kanathur, Chennai, India; Genes & Life Health Care Pvt. Ltd, Punjagutta, Hyderabad, India.
          [2 ] School of Regenerative Medicine, Manipal University, Bangalore, India.
          [3 ] Department of Surgery, Taylor's University School of Medicine, Sungai Buloh Hospital, Selangor, Malaysia.
          [4 ] Department of Biochemistry, Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi, USA.
          [5 ] School of Regenerative Medicine, Manipal University, Bangalore, India. Electronic address: rajarshi.pal@manipal.edu.
          Article
          S1465-3249(15)01101-9 NIHMS796485
          10.1016/j.jcyt.2015.10.008
          4924535
          26631828
          Copyright © 2015 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

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