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      MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale

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          Abstract

          COVID-19 disease progresses through a number of distinct phases. The management of each phase is unique and specific. The pulmonary phase of COVID-19 is characterized by an organizing pneumonia with profound immune dysregulation, activation of clotting, and a severe microvascular injury culminating in severe hypoxemia. The core treatment strategy to manage the pulmonary phase includes the combination of methylprednisolone, ascorbic acid, thiamine, and heparin (MATH+ protocol). The rationale for the MATH+ protocol is reviewed in this paper.

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          Author and article information

          Journal
          Expert Review of Anti-infective Therapy
          Expert Review of Anti-infective Therapy
          Informa UK Limited
          1478-7210
          1744-8336
          August 18 2020
          : 1-7
          Affiliations
          [1 ]Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School , Norfolk, VA, USA
          [2 ]Trauma and Life Support Center, Critical Care Service, University of Wisconsin School of Medicine and Public Health , Madison, WI, USA
          [3 ]Department of Critical Care Medicine, United Memorial, Medical Center , Houston, TX, USA
          [4 ]Department of Nephrology and Critical Care, Hackensack Meridian School of Medicine at Seton Hall University , Nutley, NJ, USA
          [5 ]Department of Nephrology and Critical Care, Community Medical Center , Toms River, NJ, USA
          [6 ]Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center , Memphis, TN, USA
          [7 ] Memphis Veterans Affairs Medical Center , Memphis, TN, USA
          Article
          10.1080/14787210.2020.1808462
          32809870
          67af79b8-d3b2-478a-b13d-be26cf0bd63c
          © 2020
          History

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