Blog
About

15
views
0
recommends
+1 Recommend
1 collections
    2
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Two folate-derived analogues from an aqueous decoction of Uncaria rhynchophylla

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Two new folate-derived analogues, named uncarophyllofolic acids A ( 1) and B ( 2), respectively, were isolated from the Uncaria rhynchophylla hook bearing stem (Gouteng in Chinese). The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey’s derivatization, along with comparison of their specific rotation and Cotton effect (CE) data with those of the biogenetically related known derivatives as well as theoretical calculations of electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway of 1 and 2, associating to folate metabolism and the previously reported orychophragines A−C from Orychophragmus violaceus, is discussed.

          Related collections

          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 928-934
          Affiliations
          1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
          Author notes
          *Corresponding author: SHI Jian-Gong, E-mail: shijg@ 123456imm.ac.cn .

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30115-3
          10.1016/S1875-5364(19)30115-3
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Sciences Foundation of China
          Award ID: 81630094
          Funded by: National Natural Sciences Foundation of China
          Award ID: 21732008
          Funded by: National Natural Sciences Foundation of China
          Award ID: 81730093
          Funded by: CAMS Innovation Fund for Medical Science of China
          Award ID: 2017-I2M-3-010
          Funded by: CAMS Innovation Fund for Medical Science of China
          Award ID: 2016-I2M-1-010
          Funded by: Drug Innovation Major Project
          Award ID: 2018ZX09711001-001-001
          This work was supported by the National Natural Sciences Foundation of China (Nos. 81630094, 21732008, and 81730093), CAMS Innovation Fund for Medical Science of China (Nos. 2017-I2M-3-010 and 2016-I2M-1-010), and the Drug Innovation Major Project (No. 2018ZX09711001-001-001).
          Categories
          Research article

          Comments

          Comment on this article