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      Congenital malformations at birth in Central India: A rural medical college hospital based data

      brief-report

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          Abstract

          OBJECTIVE:

          To study the incidence of congenital anomalies and the associated risk factors in Department of Pediatrics at Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, a rural medical college hospital in central Maharashtra.

          MATERIALS AND METHODS:

          All the intramural deliveries between 1 January 2005 and 31 July 2007 comprised 9386 births and their 9324 mothers (62 mothers gave birth to twin babies). The newborns were examined and assessed systematically for the presence of congenital anomalies, system wise distribution of anomalies and risk factors attributable.

          RESULTS:

          Out of the total 9386 deliveries, 9194 were live births and 192 were stillbirths. The total number of babies with congenital malformations was 179 (1.91%). Out of the 9262 singleton births, 177 (1.05%) were malformed, whereas 2 of the 62 pairs of twins had birth defects. Nine of the 179 malformed babies (5.02%) were still born. Prematurity, increased maternal age, increasing birth order and low birth weight were found to have a higher risk of congenital anomalies. Cardiovascular malformations were most common in live births, followed by musculoskeletal and genitourinary anomalies.

          CONCLUSION:

          Congenital anomalies are a major cause of stillbirths and infant mortality. Evaluation of cardiovascular system to rule out congenital heart disease in high-risk mothers’ babies is the important factor to be considered.

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          Most cited references18

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          Prevalence & spectrum of congenital malformations in a prospective study at a teaching hospital.

          A prospective survey for congenital malformations at birth, at a teaching hospital, over a period of two and half years on 9405 consecutive single births has shown that prevalence of major congenital malformations in live births was 1.6 per cent and in still births 16.4 per cent. There was no significant difference in the prevalence of congenital malformations between Hindus (2.0%) and Muslims (2.7%) but amongst Muslims with consanguinity the prevalence of congenital malformation was 4.6 per cent compared to 2.3 per cent in non-consanguineous Muslim spouses (P less than 0.05). Open neural tube defect was the single most common anomaly (31.7% of all malformations) occurring at a rate of 4.7 per 1000 single births, with equal prevalence of anencephaly and meningomyelocoele. Case control study showed that history of concomitant medical illness, drug intake during the first trimester, threatened abortion, hydramnios and pre-eclamptic toxaemia in the current pregnancy were significantly associated with the occurrence of congenital malformations.
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            Congenital malformations in rural Maharashtra.

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              • Article: not found

              An etiological study of congenital malformation in the newborn.

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                Author and article information

                Journal
                Indian J Hum Genet
                IJHG
                Indian Journal of Human Genetics
                Medknow Publications (India )
                0971-6866
                1998-362X
                Sep-Dec 2010
                : 16
                : 3
                : 159-163
                Affiliations
                Department of Pediatrics, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra - 442 102, India
                Author notes
                Address for correspondence: Dr. Amar Taksande, Department of Pediatrics, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra - 442 102, India. E-mail: amar_bharti2000@ 123456yahoo.co.uk
                Article
                IJHG-16-159
                10.4103/0971-6866.73412
                3009428
                21206705
                67caae5c-9696-4487-94a6-c1f058b33970
                © Indian Journal of Human Genetics

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                Brief Report

                Genetics
                cardiovascular,musculoskeletal,malformation,congenital,infant
                Genetics
                cardiovascular, musculoskeletal, malformation, congenital, infant

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