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      Lesion Preparation with Orbital Atherectomy

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          Abstract

          Despite significant improvements in stent design, severe coronary calcification continues to impede adequate stent expansion and is associated with worse clinical outcomes. Angiography is limited in its ability to detect and comprehensively characterise calcified plaque. Intravascular imaging provides information on lesion morphology guiding appropriate treatment strategies. Orbital atherectomy allows for lesion preparation of severely calcified plaque prior to stent implantation. Utilising a unique mechanism of action incorporating centrifugal forces, a standard 1.25 mm eccentrically mounted and diamond-coated burr orbits bi-directionally to ablate calcified plaque. Lesion preparation with orbital atherectomy allows for modification of calcified plaque to facilitate stent expansion.

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          Most cited references49

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          Nonoperative dilatation of coronary-artery stenosis: percutaneous transluminal coronary angioplasty.

          In percutaneous transluminal coronary angioplasty, a catheter system is introduced through a systemic artery under local anesthesia to dilate a stenotic artery by controlled inflation of a distensible balloon. Over the past 18 months, we have used this technic in 50 patients. The technic was successful in 32 patients, reducing the stenosis from a mean of 84 to 34 per cent (P less than 0.001) and the coronary-pressure gradient from a mean of 58 to 19 mm Hg (P less than 0.001). Twenty-nine patients showed improvement in cardiac function during follow-up examination. Because of acute deterioration in clinical status, emergency bypass was later necessary in five patients; three showed electrocardiographic evidence of infarcts. Patients with single-vessel disease appear to be most suitable for the procedure, and a short history of pain indicates the presence of a soft (distensible) atheroma likely to respond to dilatation. We estimate that only about 10 to 15 per cent of candidates for bypass surgery have lesions suitable for this procedure. A prospective randomized trial will be necessary to evaluate its usefulness in comparison with surgical and medical management.
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            Coronary artery calcification: pathogenesis and prognostic implications.

            Coronary artery calcification (CAC) is a risk factor for adverse outcomes in the general population and in patients with coronary artery disease. The pathogenesis of CAC and bone formation share common pathways, and risk factors have been identified that contribute to the initiation and progression of CAC. Efforts to control CAC with medical therapy have not been successful. Event-free survival is also reduced in patients with coronary calcification after both percutaneous coronary intervention (PCI) and bypass graft surgery. Although drug-eluting stents and devices for plaque modification have modestly improved outcomes in calcified vessels, adverse event rates are still high. Innovative pharmacologic and device-based approaches are needed to improve the poor prognosis of patients with CAC.
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              Ischemic outcomes after coronary intervention of calcified vessels in acute coronary syndromes. Pooled analysis from the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) and ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) TRIALS.

              This study sought to determine the frequency and impact of coronary calcification among patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS).
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                Author and article information

                Journal
                Interv Cardiol
                Interv Cardiol
                ICR
                Interventional Cardiology Review
                Radcliffe Cardiology
                1756-1477
                1756-1485
                18 November 2019
                November 2019
                : 14
                : 3
                : 169-173
                Affiliations
                [1. ] MedStar Washington Hospital Center Washington DC, US
                [2. ] St Francis Hospital, Roslyn New York NY, US
                [3. ] Cardiovascular Research Foundation New York NY, US
                [4. ] Columbia University Medical Center New York, NY, US.
                Author notes

                Disclosure: AJ has received institutional funding (unrestricted education grant) from Philips and Abbott Vascular and has served as a consultant for Philips, Abbott Vascular, Opsens Medical, and Boston Scientific. ZAA received institutional research grants to Columbia University from Abbott and Cardiovascular Systems and is a consultant to Abbott, ACIST Medical Systems, Boston Scientific, Cardinal Health, Medtronic and Canon US. All other authors have no conflicts of interest to declare.

                Correspondence: Ziad A Ali, 1700 Broadway, 8th Floor, New York, NY 10019, US. E: zaa2112@ 123456columbia.edu
                Article
                10.15420/icr.2019.20.R1
                6918479
                67d02a04-3ecf-47a8-b45f-7ecdccb0f2a2
                Copyright © 2019, Radcliffe Cardiology

                This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

                History
                : 17 July 2019
                : 01 October 2019
                Page count
                Pages: 5
                Categories
                Coronary Calcified Lesions

                orbital atherectomy,calcified lesions,percutaneous coronary intervention,optical coherence tomography,lesion preparation

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