5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Human Parechovirus: an Increasingly Recognized Cause of Sepsis-Like Illness in Young Infants.

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Human parechovirus (HPeV) is increasingly being recognized as a potentially severe viral infection in neonates and young infants. HPeV belongs to the family Picornaviridae and is currently divided into 19 genotypes. HPeV-1 is the most prevalent genotype and most commonly causes gastrointestinal and respiratory disease. HPeV-3 is clinically the most important genotype due to its association with severe disease in younger infants, which may partly be explained by its distinct virological properties. In young infants, the typical clinical presentation includes fever, severe irritability, and rash, often leading to descriptions of "hot, red, angry babies." Infants with severe central nervous system (CNS) infections are at an increased risk of long-term sequelae. Considering the importance of HPeV as a cause of severe viral infections in young infants, we recommend that molecular diagnostic techniques for early detection be included in the standard practice for the investigation of sepsis-like illnesses and CNS infections in this age group.

          Related collections

          Author and article information

          Journal
          Clin. Microbiol. Rev.
          Clinical microbiology reviews
          American Society for Microbiology
          1098-6618
          0893-8512
          January 2018
          : 31
          : 1
          Affiliations
          [1 ] Department of Paediatrics, University of Otago, Christchurch School of Medicine, Christchurch, New Zealand.
          [2 ] Canterbury Health Laboratories, Christchurch, New Zealand.
          [3 ] Department of Paediatrics, University of Otago, Christchurch School of Medicine, Christchurch, New Zealand tony.walls@otago.ac.nz.
          Article
          31/1/e00047-17
          10.1128/CMR.00047-17
          5740974
          29142080
          67d26581-3205-4ef9-bc8d-fdd5b37eaaf4
          History

          pediatrics,sepsis,HPeV,human parechovirus,infants,neonates,picornavirus

          Comments

          Comment on this article