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      Sialoglycoconjugates in Primary and Recurrent Mixed Tumors of Lacrimal Glands

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          We examined the activity of Griffonia simplicifolia II agglutinin (GS2) before and after neuraminidase treatment in 2 cases of primary benign mixed tumor (BMT) and a case of recurrent mixed tumor (MT). Histologically, each type of MT is comprised of epithelial and mesenchymal components. GS2, which showed no binding to either structural component in the primary BMT, was specifically bound to the mesenchymal component in the recurrent MT. After neuraminidase treatment, there was a marked increase in GS2-binding levels in the epithelial component of the primary BMT and in both components of the recurrent MT. These results might reveal a prominent sialylation in the recurrent MT.

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          Metastatic potential of transformed rat 3Y1 cell lines is inversely correlated with lysosomal-type sialidase activity.

          We have investigated sialidase activities in transformed rat 3Y1 cells of different metastatic potential. Only lysosome-type sialidase was apparent in the particulate fractions of 3Y1 cells and their transformants. As compared with control 3Y1 cells, src-transformed cells exhibited decreased sialidase activity, and v-fos transfer to these latter induced even more severe decrease in the sialidase activity with acquisition of high lung metastatic ability. Various lysosomal enzymes other than sialidase were hardly affected by the transformation. Sialic acid transfer to N-linked glycoproteins was slightly elevated in the transformants, but not in parallel with their metastatic potential.

            Author and article information

            Ophthalmic Res
            Ophthalmic Research
            S. Karger AG
            December 1998
            05 October 1998
            : 30
            : 6
            : 374-379
            a Department of Ophthalmology, Akita University School of Medicine, and b Section of Ophthalmology, Nakadori General Hospital, Akita, Japan
            55498 Ophthalmic Res 1998;30:374–379
            © 1998 S. Karger AG, Basel

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            Page count
            Figures: 2, Tables: 1, References: 18, Pages: 6
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