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      Nuclear bodies: Built to boost

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      Author(s): 1 , 2 , 1 ,
      Publication date (Print):
      Journal: The Journal of Cell Biology
      Publisher: The Rockefeller University Press

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          Abstract

          The classic archetypal function of nuclear bodies is to accelerate specific reactions within their crowded space. In this issue, Tatomer et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201504043) provide the first direct evidence that the histone locus body acts to concentrate key factors required for the proper processing of histone pre-mRNAs.

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          The regulation of histone synthesis in the cell cycle.

          M A Osley (1991)
          Article 0 comments Cited 88 times – based on 0 reviews     Review now
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            The Cajal body and histone locus body.

            Margaret Gall, Svetlana Deryusheva, Zehra Nizami (2010)
            The Cajal body (CB) is a nuclear organelle present in all eukaryotes that have been carefully studied. It is identified by the signature protein coilin and by CB-specific RNAs (scaRNAs). CBs contain high concentrations of splicing small nuclear ribonucleoproteins (snRNPs) and other RNA processing factors, suggesting that they are sites for assembly and/or posttranscriptional modification of the splicing machinery of the nucleus. The histone locus body (HLB) contains factors required for processing histone pre-mRNAs. As its name implies, the HLB is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action. CBs and HLBs are present throughout the interphase of the cell cycle, but disappear during mitosis. The biogenesis of CBs shows the features of a self-organizing structure.
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              Biogenesis of nuclear bodies.

              Miroslav Dundr, Tom Misteli (2010)
              The nucleus is unique amongst cellular organelles in that it contains a myriad of discrete suborganelles. These nuclear bodies are morphologically and molecularly distinct entities, and they host specific nuclear processes. Although the mode of biogenesis appears to differ widely between individual nuclear bodies, several common design principles are emerging, particularly, the ability of nuclear bodies to form de novo, a role of RNA as a structural element and self-organization as a mode of formation. The controlled biogenesis of nuclear bodies is essential for faithful maintenance of nuclear architecture during the cell cycle and is an important part of cellular responses to intra- and extracellular events.
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Cell Biol
                Journal ID (iso-abbrev): J. Cell Biol
                Journal ID (publisher-id): jcb
                Journal ID (hwp): jcb
                Title: The Journal of Cell Biology
                Publisher: The Rockefeller University Press
                ISSN (Print): 0021-9525
                ISSN (Electronic): 1540-8140
                Publication date (Print): 6 June 2016
                Volume: 213
                Issue: 5
                Pages: 509-511
                Affiliations
                [1 ]Department of Cell Biology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, North Chicago, IL 60064
                [2 ]Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
                Author notes
                Correspondence to Miroslav Dundr: mirek.dundr@ 123456rosalindfranklin.edu
                Article
                Publisher ID: 201605049
                DOI: 10.1083/jcb.201605049
                PMC ID: 4896059
                PubMed ID: 27241912
                SO-VID: 67d369e7-0b1f-4c5d-b50c-6045f5fd49e0
                Copyright © © 2016 Sawyer and Dundr
                License:

                This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

                History
                Date received : 12 May 2016
                Date accepted : 17 May 2016
                Funding
                Funded by: National Institutes of Health http://dx.doi.org/10.13039/100000002
                Funded by: National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057
                Award ID: R01GM090156
                Categories
                Subject: Commentary
                Subject: Spotlight

                ScienceOpen disciplines: Cell biology
                Data availability:
                ScienceOpen disciplines: Cell biology

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