10
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      2017 ACC/AHA blood pressure classification and incident peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Aims

          The aim of this study was to evaluate the associations of blood pressure categorization based on the 2017 American College of Cardiology and American Heart Association guideline with the risk of peripheral artery disease (PAD).

          Methods

          Among 13,113 middle-aged participants, we investigated the associations of 2017 blood pressure categories (systolic <120 and diastolic <80 mmHg (normal if no anti-hypertensive medications; reference), 120–129 and <80 (elevated), 130–139 and/or 80–89 (stage 1 hypertension), and ≥140 and/or ≥90 (stage 2 hypertension)) with incident PAD (hospitalizations with a diagnosis or leg revascularization) using Cox regression models. Analyses were separately conducted in individuals with and without anti-hypertensive medications.

          Results

          During a median follow-up of 25.4 years, 466 incident PAD occurred (271 cases in 9858 participants without anti-hypertensive medications). In participants without anti-hypertensive medications, we observed significant hazard ratios of PAD in elevated blood pressure (1.80 (1.28–2.51)) and stage 2 hypertension (2.40 (1.72–3.34)), but not in stage 1 hypertension. Analyzing systolic and diastolic blood pressure separately, higher systolic blood pressure categories showed significant associations with incident PAD in a graded fashion whereas, for diastolic blood pressure, only ≥90 mmHg did. Generally similar patterns were seen among participants on anti-hypertensive medication, while they had higher risk of PAD than those without at each blood pressure category.

          Conclusions

          Systolic blood pressure, including the category of 130–139 mmHg, showed stronger associations with incident PAD than did diastolic blood pressure. Consequently, elevated blood pressure conferred similar or even greater risk of PAD than stage 1 hypertension, with implications on how to interpret new blood pressure categories in terms of leg vascular health.

          Related collections

          Author and article information

          Journal
          European Journal of Preventive Cardiology
          Eur J Prev Cardiolog
          SAGE Publications
          2047-4873
          2047-4881
          January 2020
          July 30 2019
          January 2020
          : 27
          : 1
          : 51-59
          Affiliations
          [1 ]Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
          [2 ]Department of Kinesiology and Health Education, University of Texas at Austin, USA
          [3 ]Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, USA
          Article
          10.1177/2047487319865378
          6938694
          31362534
          67f77a4c-ef1e-4002-8880-2a1b52a198d4
          © 2020

          http://journals.sagepub.com/page/policies/text-and-data-mining-license

          History

          Comments

          Comment on this article