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      Apoptosis and cytotoxicity caused by ethoxyquin and two of its salts.

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      Cellular & molecular biology letters

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          Abstract

          In our study, we analyzed the cytotoxicity of ethoxyquin (EQ) and its two salts, ethoxyquin hydrochloride (EQ-HCL) and ethoxyquin phosphate (EQ-P). It was shown that EQ was the most cytotoxic compound (IC(50) = 0.09 mM), while the lowest cytotoxic effect was observed for EQ-P (IC(50) = 0.8 mM). The properties of ethoxyquin and its salts were also analyzed with the TUNEL method, which evaluates their ability to induce apoptosis. It was shown that EQ induced apoptosis in cultured human lymphocytes, especially at concentrations of 0.25 and 0.5 mM.

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          Author and article information

          Journal
          Cell. Mol. Biol. Lett.
          Cellular & molecular biology letters
          1425-8153
          1425-8153
          2005
          : 10
          : 1
          Affiliations
          [1 ] Department of Cytogenetics and Plant Molecular Biology, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland. ablasz@biol.uni.lodz.pl
          Article
          15809676

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