Controlled Synthesis of 3D Multi-Compartmental Particles with Centrifuge-Based Microdroplet Formation from a Multi-Barrelled Capillary

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Abstract

Controlled synthesis of micro multi-compartmental particles using a centrifuge droplet shooting device (CDSD) is reported. Sodium alginate solutions introduced in a multi-barreled capillary form droplets at the capillary orifice under ultrahigh gravity and gelify in a CaCl(2) solution. The size, shape, and compartmentalization of the particles are controlled. Co-encapsulation of Jurkat cells and magnetic colloids into Janus particles is demonstrated. The Janus particles present sensitive reaction toward magnetic fields, while the viability of the encapsulated cells is 91%.

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Anisotropy of building blocks and their assembly into complex structures.

Sharon C. Glotzer, Michael Solomon (2007)

A revolution in novel nanoparticles and colloidal building blocks has been enabled by recent breakthroughs in particle synthesis. These new particles are poised to become the 'atoms' and 'molecules' of tomorrow's materials if they can be successfully assembled into useful structures. Here, we discuss the recent progress made in the synthesis of nanocrystals and colloidal particles and draw analogies between these new particulate building blocks and better-studied molecules and supramolecular objects. We argue for a conceptual framework for these new building blocks based on anisotropy attributes and discuss the prognosis for future progress in exploiting anisotropy for materials design and assembly.

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Role of target geometry in phagocytosis.

Julie A. Champion, Samir Mitragotri (2006)

Phagocytosis is a principal component of the body's innate immunity in which macrophages internalize targets in an actin-dependent manner. Targets vary widely in shape and size and include particles such as pathogens and senescent cells. Despite considerable progress in understanding this complicated process, the role of target geometry in phagocytosis has remained elusive. Previous studies on phagocytosis have been performed using spherical targets, thereby overlooking the role of particle shape. Using polystyrene particles of various sizes and shapes, we studied phagocytosis by alveolar macrophages. We report a surprising finding that particle shape, not size, plays a dominant role in phagocytosis. All shapes were capable of initiating phagocytosis in at least one orientation. However, the local particle shape, measured by tangent angles, at the point of initial contact dictates whether macrophages initiate phagocytosis or simply spread on particles. The local shape determines the complexity of the actin structure that must be created to initiate phagocytosis and allow the membrane to move over the particle. Failure to create the required actin structure results in simple spreading and not internalization. Particle size primarily impacts the completion of phagocytosis in cases where particle volume exceeds the cell volume.

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Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up.

Piotr Garstecki, Michael J Fuerstman, Howard A Stone … (2006)

This article describes the process of formation of droplets and bubbles in microfluidic T-junction geometries. At low capillary numbers break-up is not dominated by shear stresses: experimental results support the assertion that the dominant contribution to the dynamics of break-up arises from the pressure drop across the emerging droplet or bubble. This pressure drop results from the high resistance to flow of the continuous (carrier) fluid in the thin films that separate the droplet from the walls of the microchannel when the droplet fills almost the entire cross-section of the channel. A simple scaling relation, based on this assertion, predicts the size of droplets and bubbles produced in the T-junctions over a range of rates of flow of the two immiscible phases, the viscosity of the continuous phase, the interfacial tension, and the geometrical dimensions of the device.

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Author and article information

Journal

Title: Advanced Materials

Abbreviated Title: Adv. Mater.

Publisher: Wiley-Blackwell

ISSN: 09359648

Publication date Created: March 08 2012

Publication date (Print): March 08 2012

Volume: 24

Issue: 10

Pages: 1340-1346

Article

DOI: 10.1002/adma.201102560

PubMed ID: 22311473

SO-VID: 681b02bc-f6e7-4869-8dc1-7df6ca4696cf

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http://doi.wiley.com/10.1002/tdm_license_1.1

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Controlled Synthesis of 3D Multi-Compartmental Particles with Centrifuge-Based Microdroplet Formation from a Multi-Barrelled Capillary

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Abstract

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Synthesis of 2-trifluoromethylated piperidines and azepanes

Most cited references 25

Anisotropy of building blocks and their assembly into complex structures.

Role of target geometry in phagocytosis.

Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up.

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