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      Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This overview on skin delivery considers the evolution of the principles of percutaneous ab-sorption and skin products from ancient times to today. Over the ages, it has been recognised that products may be applied to the skin for either local or systemic effects. As our understanding of the anatomy and physiology of the skin has improved, this has facilitated the development of technologies to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond. We focus on these technologies and their role in skin delivery today and in the future.

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          Multifunctional wearable devices for diagnosis and therapy of movement disorders.

          Donghee Son, Jongha Lee, Shutao Qiao … (2014)
          Wearable systems that monitor muscle activity, store data and deliver feedback therapy are the next frontier in personalized medicine and healthcare. However, technical challenges, such as the fabrication of high-performance, energy-efficient sensors and memory modules that are in intimate mechanical contact with soft tissues, in conjunction with controlled delivery of therapeutic agents, limit the wide-scale adoption of such systems. Here, we describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate. Representative examples of such systems include physiological sensors, non-volatile memory and drug-release actuators. Quantitative analyses of the electronics, mechanics, heat-transfer and drug-diffusion characteristics validate the operation of individual components, thereby enabling system-level multifunctionalities.
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            Microneedles for drug and vaccine delivery.

            Yeu-Chun Kim, Jung-Hwan Park, Mark Prausnitz (2012)
            Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990's when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encapsulate drug and fully dissolve in the skin and (iv) hollow microneedles for drug infusion into the skin. As shown in more than 350 papers now published in the field, microneedles have been used to deliver a broad range of different low molecular weight drugs, biotherapeutics and vaccines, including published human studies with a number of small-molecule and protein drugs and vaccines. Influenza vaccination using a hollow microneedle is in widespread clinical use and a number of solid microneedle products are sold for cosmetic purposes. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells. Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug efficacy and safety. Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications. Copyright © 2012 Elsevier B.V. All rights reserved.
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              Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery.

              Jicheng Yu, Yuqi Zhang, Yanqi Ye … (2015)
              A glucose-responsive "closed-loop" insulin delivery system mimicking the function of pancreatic cells has tremendous potential to improve quality of life and health in diabetics. Here, we report a novel glucose-responsive insulin delivery device using a painless microneedle-array patch ("smart insulin patch") containing glucose-responsive vesicles (GRVs; with an average diameter of 118 nm), which are loaded with insulin and glucose oxidase (GOx) enzyme. The GRVs are self-assembled from hypoxia-sensitive hyaluronic acid (HS-HA) conjugated with 2-nitroimidazole (NI), a hydrophobic component that can be converted to hydrophilic 2-aminoimidazoles through bioreduction under hypoxic conditions. The local hypoxic microenvironment caused by the enzymatic oxidation of glucose in the hyperglycemic state promotes the reduction of HS-HA, which rapidly triggers the dissociation of vesicles and subsequent release of insulin. The smart insulin patch effectively regulated the blood glucose in a mouse model of chemically induced type 1 diabetes. The described work is the first demonstration, to our knowledge, of a synthetic glucose-responsive device using a hypoxia trigger for regulation of insulin release. The faster responsiveness of this approach holds promise in avoiding hyperglycemia and hypoglycemia if translated for human therapy.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Curr Drug Deliv
                Journal ID (iso-abbrev): Curr Drug Deliv
                Journal ID (publisher-id): CDD
                Title: Current Drug Delivery
                Publisher: Bentham Science Publishers
                ISSN (Print): 1567-2018
                ISSN (Electronic): 1875-5704
                Publication date (Electronic): June 2019
                Publication date (Print): June 2019
                Volume: 16
                Issue: 5
                Pages: 444-460
                Affiliations
                School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University of Technology , Perth, , Western Australia ;

                Diamantina Institute, The University of Queensland, Translational Research Institute, QLD, 4102, , Australia, 1

                School of Pharmacy and Medical Sciences, University of South Australia , Adelaide, , Australia
                Author notes
                [* ]Address correspondence to this author at the School of Pharmacy and Biomedical Sciences, Curtin University, GPO Box U1987, Perth, 6845 Western Australia; Tel: +61892662338; Fax: +61892662769; E-mail: h.benson@ 123456curtin.edu.au
                Article
                Publisher ID: CDD-16-444
                DOI: 10.2174/1567201816666190201143457
                PMC ID: 6637104
                PubMed ID: 30714524
                SO-VID: 681d64d6-291b-445c-bd95-5181c134eab2
                Copyright © © 2019 Bentham Science Publishers
                License:

                This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

                History
                Date received : 22 November 2018
                Date revision received : 16 January 2019
                Date accepted : 25 January 2019
                Categories
                Subject: Article

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: history,skin delivery,nanotechnology,physical enhancement,microneedles,minimally invasive,transdermal technologies,targeted delivery,stratum corneum,follicular transport,wearable devices
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: history, skin delivery, nanotechnology, physical enhancement, microneedles, minimally invasive, transdermal technologies, targeted delivery, stratum corneum, follicular transport, wearable devices

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