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      Endogenous production of tumor necrosis factor alpha in combination with hyperthermia for the treatment of mice bearing Ehrlich ascites tumor.

      1 , , , ,
      Chemotherapy
      S. Karger AG

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          Abstract

          Multiple hyperthermia was found to exert an additive antitumor effect when combined with the in vivo production of tumor necrosis factor alpha (TNF-alpha) in mice bearing Ehrlich ascites tumor (EAT). TNF-alpha was produced in EAT-bearing mice by priming the animals with zymosan and subsequently challenging with lipopolysaccharide (LPS). Mice were pretreated with sulindac and D-mannoheptulose to alleviate the toxic side effects of LPS. While the ability of these tumor-bearing mice to produce TNF-alpha remained unchanged under hyperthermia, the EAT cell number was suppressed in the combined-treatment group compared with groups treated with TNF-alpha or hyperthermia alone. In the same comparison, the life span of EAT-bearing mice in the combined-treatment group was prolonged.

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          Author and article information

          Journal
          Chemotherapy
          Chemotherapy
          S. Karger AG
          0009-3157
          0009-3157
          September 1 1995
          : 41
          : 5
          Affiliations
          [1 ] Department of Biochemistry, Chinese University of Hong Kong, Shatin, Hong Kong.
          Article
          10.1159/000239370
          8521740
          6820b59f-142e-41a7-aced-03edfa3909d8
          History

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