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      Celiac disease in Tunisia: serological screening in healthy blood donors.

      Pathologie-biologie
      Adult, Blood Donors, Blood Transfusion, standards, Celiac Disease, blood, epidemiology, Enzyme-Linked Immunosorbent Assay, Female, Gliadin, immunology, Humans, Immunoglobulin A, Immunoglobulin G, Male, Prevalence, Reference Values, Tunisia

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          Abstract

          Recent epidemiological studies in Europe and in USA using antigliadin antibodies and antiendomysium antibodies for initial screening have shown that the overall prevalence of celiac disease (CD) is about 1:200 (0.5%). To screen for CD in healthy blood donors in Tunisia. Sera from 2500 healthy blood donors (median age: 21 years, 70% men and 30% women) were screened for IgG-antigliadin antibodies and IgA-antigliadin antibodies with an enzyme-linked immunosorbent assay. All sera with positive antigliadin antibodies were tested for antiendomysium antibodies using human umbilical cord cryosections as substrate. Seven healthy blood donors (median age: 21 years; four men, three women) have antiendomysium antibodies. The prevalence of antiendomysium antibodies in healthy blood donors in Tunisia is 1:355 (0.28%). On the basis of a high specificity of the antiendomysium antibodies, it is likely that the seven blood donors identified in this study have CD. These data suggest that CD is frequent in Tunisia.

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